![]() ![]() Monitoring synaptic transmission in primary neuronal cultures using local extracellular stimulation. RIM proteins tether Ca2+ channels to presynaptic active zones via a direct PDZ-domain interaction. Activity-dependent IGF-1 exocytosis is controlled by the Ca(2+)-sensor synaptotagmin-10. Distinct molecular mechanisms and divergent endocytotic pathways of AMPA receptor internalization. Nonuniform probability of glutamate release at a hippocampal synapse. Heterogeneous release properties of visualized individual hippocampal synapses. The probability of transmitter release at a mammalian central synapse. Heterogeneity of release probability, facilitation, and depletion at central synapses. ![]() A force-plate actometer for quantitating rodent behaviors: illustrative data on locomotion, rotation, spatial patterning, stereotypies, and tremor. Neurexin and neuroligin mediate retrograde synaptic inhibition in C. Drosophila neuroligin 2 is required presynaptically and postsynaptically for proper synaptic differentiation and synaptic transmission. Alpha-neurexins couple Ca2+ channels to synaptic vesicle exocytosis. Presynaptic Nrxn3 alternative splicing trans-synaptically controls postsynaptic AMPA receptor trafficking. Cartography of neurexins: more than 1000 isoforms generated by alternative splicing and expressed in distinct subsets of neurons. Cartography of neurexin alternative splicing mapped by single-molecule long-read mRNA sequencing. Variations in the obesity genes FTO, TMEM18 and NRXN3 influence the vulnerability of children to weight gain induced by short sleep duration. Association of a polymorphism in the NRXN3 gene with the degree of smoking in schizophrenia: a preliminary study. Novak, G., Boukhadra, J., Shaikh, S.A., Kennedy, J.L. Genome-wide suggestive linkage of opioid dependence to chromosome 14q. Nrxn3 upregulation in the globus pallidus of mice developing cocaine addiction. Neurexin 3 polymorphisms are associated with alcohol dependence and altered expression of specific isoforms. Association of neurexin 3 polymorphisms with smoking behavior. Association between neurexin 1 (NRXN1) polymorphisms and the smoking behavior of elderly Japanese. Neurexin 1 (NRXN1) deletions in schizophrenia. Disruption of neurexin 1 associated with autism spectrum disorder. The role of neurexins in schizophrenia and autistic spectrum disorder. Neurexins: synaptic cell surface proteins related to the alpha-latrotoxin receptor and laminin. Ushkaryov, Y.A., Petrenko, A.G., Geppert, M. Unusual cleaved signal sequences in receptor-like neuronal cell-surface proteins. Conserved domain structure of beta-neurexins. Structure and evolution of neurexin genes: insight into the mechanism of alternative splicing. Neuroligins and neurexins link synaptic function to cognitive disease. The role of neurexins and neuroligins in the formation, maturation, and function of vertebrate synapses. Krueger, D.D., Tuffy, L.P., Papadopoulos, T. Neurexins and neuroligins: recent insights from invertebrates. A matter of balance: role of neurexin and neuroligin at the synapse. Thus, our data indicate that neurexin-3 performs distinct essential pre- or postsynaptic functions in different brain regions by distinct mechanisms.īang, M.L. In cultured neurons and acute slices of the olfactory bulb, however, intracellular sequences of presynaptic neurexin-3 were selectively required for GABA release. Specifically, we found that, in cultured neurons and acute slices of the hippocampus, extracellular sequences of presynaptic neurexin-3 mediated trans-synaptic regulation of postsynaptic AMPA receptors. Using newly generated constitutive and conditional knockout mice that target all neurexin-3α and neurexin-3β isoforms, we found that neurexin-3 was differentially required for distinct synaptic functions in different brain regions. The specific functions of neurexins, however, remain largely unknown because no conditional neurexin knockouts are available and targeting all α- and β-neurexins produced by a particular gene is challenging. Α- and β-neurexins are presynaptic cell-adhesion molecules whose general importance for synaptic transmission is well documented. ![]()
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